Use the tablet left-handed
Some tablets have hardware buttons on one side. The tablet can be rotated 180 degrees to position these buttons for left-handed people. To switch the orientation to left-handed:
Click the icon at the far right of the menu bar and select System Settings.
Open Wacom Graphics Tablet.
If no tablet is detected, you'll be asked to Please plug in or turn on your Wacom tablet.
Switch Left-Handed Orientation to ON.